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PNHSource

Paroxysmal nocturnal hemoglobinuria (PNH) is a progressive and life-threatening disease that causes thrombosis, end organ damage, impaired quality of life, and increased mortality.^1-3

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Important facts about PNH:

Chronic hemolysis is the underlying cause of progressive morbidities and
mortality in PNH⁴
Thrombosis and renal failure are leading causes of death in PNH^3,5
Early diagnosis drives effective PNH management

About PNH

Get detailed information on PNH symptoms, treatment, and research.

PNH Symptoms

What are the general symptoms of PNH? Learn more.

PNH Diagnostic Brochure

Learn more about why targeting high-risk patients for early diagnosis can help drive effective PNH management.

Monitoring hemolysis with lactate dehydrogenase (LDH) provides a more accurate assessment of PNH
Evaluate your patients with myelodysplastic syndromes (MDS) at diagnosis and your patients with aplastic anemia (AA) at diagnosis and annually

Educational Videos

Watch videos of physicians who are leading experts in the PNH field. Learn more about the severity of PNH from Dr. Wendell Rosse, and how to identify and diagnose your high-risk patients from Dr. Jeff Patton.

For Patients & Caregivers

Get PNH information and resources tailored for patients and caregivers.

References: 1. Hillmen P, Lewis SM, Bessler M, Luzzatto L, Dacie JV. Natural history of paroxysmal nocturnal hemoglobinuria. N Engl J Med. 1995;333:1253-1258. 2. Socié G, Mary J-Y, de Gramont A, et al, for the French Society of Haematology. Paroxysmal nocturnal haemoglobinuria: long-term follow-up and prognostic factors. Lancet. 1996;348:573-577. 3. Nishimura J-I, Kanakura Y, Ware RE, et al. Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan. Medicine. 2004;83:193-207. 4. Hillmen P, Young NS, Schubert J, et al. The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria. N Engl J Med. 2006;355:1233-1243. 5. Rother RP, Bell L, Hillmen P, Gladwin MT. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA. 2005;293:1653-1662.

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