PNH Diagnosis & Treatment

Diagnostic Pathway for PNH

 

*Adapted from Parker, et al, Blood, 2005.

Evaluate high-risk patient populations for PNH.

Early diagnosis drives effective PNH management

Diverse PNH symptomatology may complicate and delay diagnosis. Disease progression resulting from serious clinical sequelae reinforces the importance of early diagnosis. Accordingly, the current availability of an effective PNH treatment option warrants testing appropriate patients. Click below to learn more about the PNH Diagnostic Pathway for high-risk patients, including those with aplastic anemia, myelodysplastic syndromes, and unexplained thromboses.
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Flow Cytometry

Flow cytometry — a simple, inexpensive, peripheral blood test — is the standard diagnostic test for PNH. Threshold values for a positive PNH test may vary from lab to lab; therefore, samples should be sent to a high-sensitivity lab with the ability to detect clones as low as 0.01%.

Ordering flow cytometry for high-risk patients? Here are a few recommendations.

Learn more about new reagents for flow cytometry

Looking for a high-sensitivity lab to send flow cytometry tests to? View a listing of labs.

Treatment Options

Treatments include the first humanized monoclonal antibody (MAb) therapy approved for the long-term management of PNH, palliative therapies like transfusions and steroids, and bone marrow transplantation (BMT).

Monoclonal Antibody Therapy

Palliative Therapies

Bone Marrow Transplantation


References: 1. Sugimori C, Chuhjo T, Feng X, et al. Minor population of CD55-CD59- blood cells predicts response to immunosuppressive therapy and prognosis in patients with aplastic anemia. Blood. 2006;107:1308-1314.