Diagnostic Pathway

The life-threatening and progressive nature of PNH warrants early identification in high-risk patient populations

Evaluate high-risk patients with the PNH Diagnosis Pathway; the current availability of an effective PNH treatment option warrants testing appropriate patients

Diagnostic Pathway for PNH
*Adapted from Parker, et al, Blood, 2005.

The life-threatening and destructive consequences of hemolysis (as measured by LDH) warrant early identification in high-risk subpopulations

Chronic hemolysis is the underlying cause of progressive morbidities and mortality in PNH2; therefore, reducing chronic hemolysis is the primary goal of PNH treatment. Early identification of PNH in high-risk populations is optimal for long-term disease management. Use the PNH Diagnostic Pathway displayed above to help identify those patients in your practice who may be at risk for PNH.

Click on the following links for more information regarding diagnosis in populations at high risk for PNH:


References: 1. Sugimori C, Chuhjo T, Feng X, et al. Minor population of CD55-CD59- blood cells predicts response to immunosuppressive therapy and prognosis in patients with aplastic anemia. Blood. 2006;107:1308-1314. 2. Hillmen P, Young NS, Schubert J, et al. The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria. N Engl J Med. 2006;355:1233-1243.