PNH clones in AA/MDS occur frequently, with important prognostic and therapeutic implications
PNH cells (granulocytes) are common in bone marrow disorders2,3
- Approximately 70% of patients with AA have PNH clones2*
- As many as 42% of patients with MDS have PNH clones3*
Evaluate your AA patients for PNH at diagnosis and annually, as clones may expand rapidly and unpredictably over time.4,5
Conduct high-sensitivity flow cytometry on peripheral blood in addition to bone marrow aspirate to confirm the presence of PNH during evaluation for AA, MDS, or unexplained cytopenias
