Your PNH differential diagnosis should include both flow cytometry and LDH
- Appropriate clinical assessment of the patient along with lab results — flow cytometry and LDH to determine the degree of hemolysis — provides a more complete diagnostic picture
- PNH is a heterogeneous disease that presents uniquely in each patient. No one sign or symptom provides a diagnosis of PNH
- A complete patient assessment, including a thorough review of systems, is essential to identify the presence or absence of symptoms and establish the burden of disease for an individual patient

Reference: 1. Hillmen P, Young NS, Schubert J, et al. The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria. N Engl J Med. 2006;355:1233-1243.