Add PNH to your hypercoagulation panel in patients with unexplained thrombosis
Venous thromboembolism (VTE) is 62x more likely to occur in PNH vs 2x to 8x more likely
for other hypercoagulable states1
- Venous or arterial thromboses account for approximately 40% to 67% of PNH-related deaths4
- First thrombotic event (TE) increases risk for death 5- to 10-fold4
- Incidence of first-ever ischemic stroke (FEIS) is elevated in PNH patients; age of FEIS in the PNH population (median age 46) is markedly lower than the general population (median age 72)5,6
Patients with PNH have a higher relative risk of developing a VTE than other hypercoagulable states.
References: 1. De Stefano V, Rossi E, Paciaroni K, Leone G. Screening for inherited thrombophilia: indications and therapeutic implications. Haematologica. 2002;87:1095-1108. 2. Hill A, Platts PJ, Smith A, et al. The incidence and prevalence of paroxysmal nocturnal hemoglobinuria (PNH) and survival of patients in Yorkshire [ASH abstract]. Blood. 2006;108: Abstract 985. 3. De Stefano V, Rossi E, Za T, Leone G. Prophylaxis and treatment of venous thromboembolism in individuals with inherited thrombophilia. Semin Thromb Hemost. 2006;32:767-780. 4. Hillmen P, Muus P, Duhrsen U, et al. Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria. Blood. 2007;110:4123-4128. 5. Data on file, Alexion Pharmaceuticals Inc. 6. Gostynski M, Engelter S, Papa S, Ajdacic-Gross V, Gutzwiller F, Lyrer P. Incidence of first-ever ischemic stroke in the Canton Basle-City, Switzerland. J Neurol. 2006;253:86-91.