Bone Marrow Transplantation

Bone Marrow Transplantation

Bone marrow transplantation (BMT) presents risks and is feasible for only select patients. There are several factors to consider. Consequently, it is usually reserved for those with severe underlying bone marrow dysfunction. Your patient’s medical history as well as the availability of an appropriate donor are both factors in determining whether BMT is an option for your patient.

In general, BMT is indicated in patients with severe bone marrow hypoplasia or serious thrombosis. An HLA-identical sibling is the ideal match and offers the best chance of success.1,2

Even people who undergo a successful BMT can have long-term complications (e.g., graft vs. host disease).


References: 1. Parker C, Omine M, Richards S, et al; for the International PNH Interest Group. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood. 2005;106:3699-3709. 2. Rosse WF. Treatment of paroxysmal nocturnal hemoglobinuria. Blood. 1982;60:20-23.