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PNH in Coombs-Negative Hemolytic Anemia and Hemoglobinuria
Who to Test for PNH: Coombs-Negative Hemolytic Anemia and Hemoglobinuria1,2
Coombs-Negative Hemolytic Anemia
Patients with hemolytic anemia who are Coombs-negative or have concomitant iron deficiency are more likely to present with a PNH clone.2
PNH Consensus Guidelines recommend testing all patients with Coombs-negative hemolytic anemia for PNH.2
Hemoglobinuria
According to the PNH Consensus Guidelines from the Clinical Cytometry Society, "any patient with unexplained hemoglobinuria should be tested for PNH."2
- 47% of patients with hemoglobinuria tested positive for PNH clone3
- However, only 26% of patients reported hemoglobinuria at diagnosis4
Perform PNH flow cytometry on all patients with Coombs-negative hemolytic anemia and/or hemoglobinuria.
Next: PNH in AA and RA-MDS
1. Hillmen P, Lewis SM, Bessler M, Luzzatto L, Dacie JV. N Engl J Med. 1995;333:1253-1258. 2. Borowitz MJ, Craig FE, DiGiuseppe JA, et al; for Clinical Cytometry Society. Cytometry Part B Clin Cytom. doi:10.1002/cyto.b.20525. 3. Data on file, Dahl-Chase Diagnostic Services. 4. Dacie JV, Lewis SM. Ser Haematol. 1972;5:3-23.
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