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PNH in Unexplained Cytopenias
Who to Test for PNH: Unexplained Cytopenias
91% of Patients With PNH Initially Present With Concomitant Cytopenias1
- Cytopenias indicate underlying bone marrow dysfunction—and raise the index of suspicion for PNH
- Thrombocytopenic patients with PNH are at greater risk for thromboembolism3
- Evidence of platelet consumption3
- PNH Consensus Guidelines recommend testing patients with cytopenias and hemolysis or thrombosis, or patients with cytopenias that remained unexplained after thorough workup4
Evaluate Patients with Unexplained Cytopenias with Flow Cytometry to Rule PNH In or Out
1. Dacie JV, Lewis SM. Ser Haematol. 1972;5:3-23. 2. Peffault de Latour R, Mary JY, Salanoubat C, Terriou L, et al; on behalf of the French Society of Hematology and of the French Assocation of Young Hematologists. Blood. 2008;112:3099-3106. 3. Socié G, Muus P, Schrezenmeier H, et al. [ASH abstract]. Blood. 2009;114: Abstract 4030. 4. Borowitz MJ, Craig FE, DiGiuseppe JA, et al; for Clinical Cytometry Society. Cytometry Part B Clin Cytom. doi:10.1002/cyto.b.20525.
The most sensitive and informative test to diagnose PNH.
Treatment options for PNH include monoclonal antibodies, bone marrow transplantation, and palliative therapies.