PNH Publications, Brochures, and Videos

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Diagnosing PNH

Abou Antoun S, El-Haddad B, Wehbe E, Schulz T. Lysis and thrombosis: manifestation of the same disease. Am J Hematol. 2008;83:505-507.

Nebe T, Schubert J, Gutensohn K, Schrezenmeier H. Flow cytometric analysis of GPI-deficient cells for the diagnosis of paroxysmal nocturnal hemoglobinuria (PNH). J Lab Med. 2003;27:257-265.

PNH and Renal Disease

Clark DA, Butler SA, Braren V, Hartmann RC, Jenkins DE Jr. The kidneys in paroxysmal nocturnal hemoglobinuria. Blood. 1981;57:83-89.

PNH Review Articles

Hill A, Platts PJ, Smith A, et al. The incidence and prevalence of paroxysmal nocturnal hemoglobinuria (PNH) and survival of patients in Yorkshire (ASH abstract). Blood. 2006;108: Abstract 985.

Hill A, Richards SJ, Hillmen P. Recent developments in the understanding and management of paroxysmal nocturnal haemoglobinuria. Br J Haematol. 2007;137:181-192.

Hillmen P, Lewis SM, Bessler M, Luzzatto L, Dacie JV. Natural history of paroxysmal nocturnal hemoglobinuria. N Engl J Med. 1995;333:1253-1258.

Luzzatto L, Gianfaldoni G. Recent advances in biological and clinical aspects of paroxysmal nocturnal hemoglobinuria. Int J Hematol. 2006;84:104-112.

Moyo VM, Mukhina GL, Garrett ES, Brodsky RA. Natural history of paroxysmal nocturnal haemoglobinuria using modern diagnostic assays. Br J Haematol. 2004;126:133-138.

Parker C, Omine M, Richards S, et al, for the International PNH Interest Group. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood. 2005;106:3699-3709.

Peffault de Latour R, Mary JY, Salanoubat C, et al; for the French Society of Hematology and the French Association of Young Hematologists. Paroxysmal nocturnal hemoglobinuria: natural history of disease subcategories. Blood. 2008;112:3099-3106.

Richards SJ, Hill A, Hillmen P. Recent advances in the diagnosis, monitoring, and management of patients with paroxysmal nocturnal hemoglobinuria. Cytometry B Clin Cytom. 2007;72:291-298.

Rother RP. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA. 2005;293(13):1653-1662.

Socié G, Mary JY, de Gramont A, et al. Paroxysmal nocturnal haemoglobinuria: long-term follow-up and prognostic factors. French Society of Haematology. Lancet. 1996;348:573-577.

PNH and Bone Marrow Disorders

Ishikawa T, Tohyama K, Nakao S, et al. A prospective study of cyclosporine A treatment of patients with low-risk myelodysplastic syndrome: presence of CD55(-)CD59(-) blood cells predicts platelet response. Int J Hematol. 2007;86:150-157.

Maciejewski JP, Rivera C, Kook H, Dunn D, Young NS. Relationship between bone marrow failure syndromes and the presence of glycophosphatidyl inositol-anchored protein-deficient clones. Br J Haematol. 2001;115:1015-1022.

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Are there PNH patients in your practice? PNH: Diagnostic tools and techniques

This brochure supports healthcare professionals in early diagnosis of PNH, which can help drive effective patient management.

Symptom Assessment Card

This card provides healthcare professionals with an easy tool when assessing PNH symptoms.

PNH Registry Brochure

This brochure provides an overview of the PNH Registry and explains how physicians and patients can become a part of it.

Understanding PNH: A guide for patients and their caregivers

A comprehensive brochure for patients and their caregivers that provides education and practical information about PNH.

Diagnostic Challenges: Case Studies in PNH

This casebook displays the variable presentation of PNH and provides healthcare professionals with insight into diagnosing the disease.

This selection of videos from PNH thought leaders Jeff Patton, MD, and Wendell Rosse, MD, cover a wide variety of topics related to PNH.

PNH Publications, Brochures, and Videos

Implementation of the CCS Guidelines Videos

High-Risk Patient Groups Videos

PNH Overview

Consequences of Hemolysis

PNH Diagnosis

PNH Management

Patient Case Studies

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