Release of Free Hemoglobin

Pathobiological Effects of Hemolysis¹

A direct result of hemolysis of RBCs is the release of hemoglobin into the plasma. This leads to circulating free hemoglobin, resulting in heme-scavenging mechanisms including nitric oxide scavenging and a decrease in nitric oxide synthesis.¹

The resultant nitric oxide depletion causes¹:

• Endothelial cell dysfunction
• Impaired regulation of smooth muscle tone
• Platelet activation and aggregation
• Local vasoconstriction

These pathobiological effects can lead to pulmonary and systemic hypertension, CKD, erectile dysfunction, dysphagia, abdominal pain, and intravascular thrombosis, all of which are sequelae of PNH.¹

Click here for a video about nitric oxide and free hemoglobin in PNH

Next: Consequences of Hemolysis