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Signs and Symptoms
Common Symptoms of Hemolysis
Signal the Underlying Threat of
Serious Consequences
A patient may present with any of the common symptoms of PNH such as abdominal pain, dyspnea, or hemoglobinuria. But just like an iceberg hiding its true magnitude beneath the water, these symptoms may be indicative of more serious consequences that lie beneath the surface, such as thrombosis, pulmonary hypertension, or chronic kidney disease.
The Common Symptoms of PNH Include the Following:
- Abdominal pain
- Anemia
- Dysphagia
- Dyspnea
- Erectile dysfunction
- Fatigue
- Hemoglobinuria
- Impaired quality of life (QoL)
These symptoms, however, may be indicative of more serious underlying consequences of the disease, such as:
- Acute renal failure
- Cardiac dysfunction
- Chronic kidney disease
- Deep vein thrombosis
- Hepatic failure
- Ischemic bowel
- Pulmonary hypertension
- Stroke or TIA
If a patient exhibits any of the early presenting symptoms, consider therapeutic intervention as this may help to avoid or delay more serious downstream complications of PNH.
Patients with certain conditions may be at higher risk for PNH.
Early diagnosis can positively impact long-term patient outcomes in PNH.
Learn more about the importance of a full clinical assessment