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Who to Test for PNH
The identification of PNH cells has important prognostic and therapeutic implications.1,2 PNH Consensus Guidelines and the International PNH Interest Group recommend continued monitoring of patients at higher risk for PNH.1,3
Next: High-Risk Patient Groups: Coombs-Negative Hemolytic Anemia and Hemoglobinuria
1. Parker C, Omine M, Richards S, et al; for the International PNH Interest Group. Blood. 2005;106:3699-3709. 2. Dunn DE, Tanawattanacharoen P, Boccuni P, et al. Ann Intern Med. 1999;131:401-408. 3. Borowitz MJ, Craig FE, DiGiuseppe JA, et al; for Clinical Cytometry Society. Cytometry Part B Clin Cytom. doi:10.1002/cyto.b.20525.
Some of the consequences of hemolysis include stroke or TIA, pulmonary embolism or DVT, and end-organ damage to the brain, liver, gastrointestinal tract, or lungs.
The most sensitive and informative test to diagnose PNH.