Hemolysis: The threat you cannot see

Taking action is key to fighting PNH

Ongoing hemolysis is the root cause of the signs, symptoms, and serious health problems of PNH.

Hemolysis happens when red blood cells burst. With PNH, hemolysis is always happening — even if you can’t see or feel it.

Why is hemolysis so bad?

When red blood cells burst, they release hemoglobin. Hemoglobin is good for the body when it’s inside your red blood cells.

When it’s outside, it is very dangerous and can harm your body in many ways. Over time, it is very dangerous and can build up and cause serious health problems that are hard to predict.

These health problems can include:

• Kidney failure
• Blood clots
• Stroke
• Heart attack
• Damage to organs such as your liver, brain, and lungs

How will I know hemolysis is happening?

You cannot always see or feel hemolysis, which makes it tough to manage. The results of it often can affect the way you feel and live your life.

Left unattended, hemolysis can make you feel very tired and weak. It can also lead to signs and symptoms like:

• Fatigue
• Impaired quality of life
• Trouble swallowing
• Stomach pain
• Shortness of breath
• Dark-colored urine
• Erectile dysfunction (ED)

PNH is progressive

PNH is a serious and progressive disease. This means your disease can get worse over time, increasing your risk of major PNH health problems, including some that can be life threatening.

You CAN take control of PNH

Fortunately, by addressing PNH early and aggressively, people with PNH can live fuller lives. By working closely with your doctor, you may be able to keep the risks of PNH at bay.

*Fictitious patient and account. Adapted from real patient stories.