Clinical Manifestations

Common symptoms in a patient with PNH can be manifestations of devastating consequences from intravascular hemolysis1,2

Common PNH symptoms

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Doctor Rosse video

Listen to Wendell Rosse, MD, talk about the need to explain to patients with PNH about the progressive and chronic nature of their disease.

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PNH Medical Expert PNH Medical Expert

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References: 1. Rachidi S, Musallam KM, Taher AT. Eur J Intern Med. 2010;21:260-267. 2. Borowitz MJ, Craig FE, DiGiuseppe JA, et al; for Clinical Cytometry Society. Cytometry Part B. 2010;78B:211-230. 3. Hillmen P, Elebute M, Kelly R, et al. Am J Hematol. 2010;85:553-559. 4. Kelly R, Richards S, Hillmen P, et al. Ther Clin Risk Manag. 2009;5:911-921. 5. Hill A, Sapsford RJ, Scally A, et al. Br J Haematol. 2012;158:409-414. 6. Hillmen P, Muus P, Dührsen U, et al. Blood. 2007;110:4123-4128. 7. Adams T, Fleischer D, Marino G, et al. Dig Dis Sci. 2002;47:58-64. 8. Brodsky RA. In: Hoffman R, Benz EJ Jr, Shattil SJ, et al, eds. Hematology: Basic Principles and Practice. 4th ed. Philadelphia, PA: Elsevier Churchill Livingstone; 2005:419-427.