High-Risk Patient Groups

Early diagnosis can positively impact long-term patient outcomes1,2

The International Clinical Cytometry Society (ICCS) and International PNH Interest Group (IPIG) recommend continued monitoring of patients at higher risk for PNH.1,3

  • In an analysis of high-risk patients, high-sensitivity flow cytometry (HSFC) detected a PNH clone in 1 out of 16 patients (421/6897)4
  • 1 out of 27 patients (255/6897) had a PNH clone size of >1%4

Learn more about these high-risk patient groups by clicking on the blue boxes.

*Study description: An analysis of the incidence of PNH clones in 6897 patients recommended for testing according to guidelines from the International Clinical Cytometry Society (ICCS) and International PNH Interest Group (IPIG).4

Includes all MDS subtypes.

0.01% PNH cell threshold.

Symptoms of PNH

The diverse and common symptomatology of PNH can delay diagnosis. Find out about the variety of symptoms that can occur in a patient with PNH.

PNH Medical Expert PNH Medical Expert

Do you have any questions about PNH? Contact a medical expert for more information.

Doctor Patton video

Watch Jeff Patton, MD, talk about how the ICCS and IPIG guidelines have helped to identify patients with PNH who would otherwise have been missed.

References: 1. Borowitz MJ, Craig FE, DiGiuseppe JA, et al; for Clinical Cytometry Society. Cytometry Part B. 2010;78B:211-230. 2. Richards SJ, Barnett D. Clin Lab Med. 2007;27:577-590. 3. Parker C, Omine M, Richards S, et al; for International PNH Interest Group. Blood. 2005;106:3699-3709. 4. Movalia M, Illingworth A, Weitz I, et al. Incidence of PNH clones by diagnostic code utilizing high sensitivity flow cytometry. Poster presented at the 53rd Annual Meeting of the American Society of Hematology; December 10-13, 2011; San Diego, CA. Abstract 1033.